Medical Genetics & Human Health series


 

 

E-Books & Downloads


 

Gene Manipulation

Author: Jake Ireland 

Published 15 June 2015

SYNOPSIS

Students are familiarised with techniques whereby recombinant DNA is characterised, manipulated and expressed. The principles underlying this methodology are emphasised and skills are developed in analysing examples of data from bacterial and eukaryotic systems. 

LEARNING OUTCOMES 
At the end of this module, you should be able to:

  • demonstrate an understanding of the essentials of gene manipulation techniques.
  • synthesise concepts from earlier L2 modules.
  • describe processes to obtain a cloned coding sequence.
  • critically evaluate problems of heterologous gene expression and product recovery.
  • demonstrate comprehension that nucleic acid and protein methodologies are mutually reinforcing approaches.
  • critically appraise the applications of these techniques to a wide range of biological problems. 
  • demonstrate skills in evaluating data from these techniques for him/her self.

 

Animal Development

Author: Jake Ireland

Published: 15 June 2015

SYNOPSIS

The module provides an understanding of the principles of animal development, introducing critical genes and their products that play roles in regulating metazoan development. Classical embryology will be integrated with contemporary molecular investigations into developmental mechanisms.

LEARNING OUTCOMES

The student will be able to:-

  • Demonstrate an in-depth understanding of how developmental fate is determined.
  • Critically assess the role of induction in coordinating development.
  • Appreciate the evolutionary conservation of developmental mechanisms.
  • Interpret results from several advanced research techniques employed in developmental analysis.

 

Clinical Biochemistry and Physiology

Author: Jake Ireland

Published: 1 May 2015


 

Mass spectrometry

Author: Jake Ireland

Published: 29 April 2015


 

Genetics and Cancer

Author: Jake Ireland

Published: 25 April 2015

Module Synopsis

This module will provide students with an advanced understanding about the genetic mechanisms involved in carcinogenesis, and how these underlying processes and molecules affect the human body.

Learning Outcomes

By the end of the module the student should be able to:

  • Demonstrate advanced knowledge of the genetic mechanisms, processes and molecules involved    in the normal human state compared to the changes that occur in disease states, primarily human   cancers.
  • Identify a variety of diagnostic processes and treatments in common human cancers.
  • Critically analyse data relating to clinical and genetic status using a variety of techniques.

 

Mutations and Human Health

Author: Jake Ireland

Published: 21 April 2015

Module Synopsis

The module provides an advanced understanding of the effects of carcinogenic agents on human health, and develops skills in investigating and assessing DNA damage caused by genotoxic compounds to improve the prevention and treatment of cancer and human disease. 

Learning Outcomes

  • Demonstrate a critical understanding of carcinogenic compounds, and their uses and existence in a historical context.
  • Demonstrate a critical understanding of the mode of action of DNA damaging agents with respect to their carcinogenicity, and be able to critically discuss exposure through to cancer.
  • Evaluate genetic toxicological data in a qualitative and quantitative manner.
  • Demonstrate critical knowledge of the current genotoxic compounds in the public eye, and be able to have an unbiased view on the potential carcinogenicity of these agents.
  • Implicate genetic toxicology methodology to assess nano-safety and show a critical understanding of the development and uses of nano-materials and their impact on human health for risk assessment.

 

Aspects of Human Sensory and Metabolic Biochemistry

Author: Jake Ireland

Published: 8 February 2015

MODULE SYNOPSIS  

This module introduces students to selected examples of inborn errors of metabolism,

the, physiological consequences of those errors and their management. The biochemistry and physiology of visual transduction, olfaction and sensory biochemistry is covered. Aspects of central nervous system biochemistry such as the provision of energy for the brain, the metabolism of neurotransmitters and the role of neurotransmitters in controlling behaviour is also considered.  

LEARNING OUTCOMES  

  • At the end of this module students should be able to:
  • demonstrate a detailed knowledge of the biochemistry underlying the process of visual transduction, critically appreciate the inter-relationship between sensory physiology and biochemistry,
  • demonstrate an understanding of the peculiarities of the central nervous system biochemistry.
  • demonstrate an understanding of the concept of inborn errors of metabolism and their consequences
  • demonstrate an integrated knowledge of biochemical pathways and their relevance to human health.